Platelet activating factor produced by yeast.

Short Communication Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat

Centre for Immuno logy, St. Vincent’s Hosp ita l, Darlinghurst, 2010, NSW, Austra lia ; Department o f Neuro logy, Unive rsity o f Kentuck y, Lexington, KY, USA; Ray Williams Biome d ica l Mass Sp ec trome try Fa cility, Unive rsity o f New South Wales, Sydney, 2052, Australia ; Nationa l Centre in HIV Ep idemio logy and Clinica l Re search , Darlinghurst, 2010, NSW, Australia; Department o f H...

Platelet activating factor revisited.

Platelet-activating factor.

Platelet-activating factor is a phospholipid with diverse potent physiological effects. Its actions are achieved at concentrations as low as IO-‘” M in some systems and almost always by lo-’ M as an intercellular messenger. The molecular structure of PAF was discovered through parallel investigations of two different biological activities: a factor in the blood of rabbits undergoing anaphylaxis...

Platelet-activating factor.

Our ability to chemically characterize and synthesize this autacoid of allergy and inflammation has given us a unique opportunity to study these important molecules in a highly disciplined fashion. It has also opened the door to a vista of research approaches to define PAF's normal physiologic role as well as its actions as an immunopathologic mediator. Recent work is described.

Platelet activating factor produced in vitro by Kaposi's sarcoma cells induces and sustains in vivo angiogenesis.

Imbalance in the network of soluble mediators may play a pivotal role in the pathogenesis of Kaposi's sarcoma (KS). In this study, we demonstrated that KS cells grown in vitro produced and in part released platelet activating factor (PAF), a powerful lipid mediator of inflammation and cell-to-cell communication. IL-1, TNF, and thrombin enhanced the synthesis of PAF. PAF receptor mRNA and specif...